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DOSAGE FORMS AND STRENGTHS

Tablets intended for dispersion in a liquid immediately prior to oral administration: 40 mg.

Dosage and Administration

Initiation of detoxification and maintenance treatment: A single dose of 20 to 30 mg may be sufficient to suppress withdrawal syndrome. Do not abruptly discontinue DISKETS dispersible tablets in a physically dependent patient

Maintenance treatment: Clinical stability is most commonly achieved at doses between 80 to 120 mg/day. For Opioid-naive patients, the dose is 2.5 mg orally every 8-12hr.

For Pain:

Adults:

Usual single dose, 5 to 10mg orally. Owing to its long plasma half-life, caution with repeated dosage should be observed in the very ill or elderly. The usual initial dose should be 5 to 10mg, 6 to 8 hourly, later adjusted to the degree of pain relief obtained.

For Addiction:

Adults:

Initially 10 – 20mg per day, increasing by 10 – 20mg per day until there are no signs of withdrawal or intoxication. The usual dose is 40 – 60mg per day. The dose is adjusted according to the degree of dependence with the aim of gradual reduction.

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Dosage for detoxification of opioid addiction
Adult dosage (ages 18–64 years)

Typical starting dosage: 20–30 mg.
Dosage increases: After waiting two to four hours, your doctor may give you an extra 5–10 mg.
Typical dosage: For short-term detoxification, the typical dosage is 20 mg taken two times per day for two to three days. Your doctor will slowly decrease your dosage and watch you closely.
Maximum dosage: On the first day, you shouldn’t take more than 40 mg total.

Dosage for maintenance of opioid addiction
Adult dosage (ages 18–64 years)

The standard dosage ranges between 80–120 mg per day. Your doctor will determine a dosage that’s right for you.

Methadone Side Effects

Methadone’s side effects are similar to those associated with other opioid drugs. These include: Constipation, Sleepiness or drowsiness, Nausea or vomiting, Forgetfulness, Lightheadedness or dizziness, Impaired cognition or confusion, Impaired balance or coordination. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Sweating (drink at least 2 liters of water each day to prevent dehydration),
difficulty passing urine, loss of appetite, nausea and vomiting, abdominal cramps, constipation, aching muscles and joints, irregular periods, low sex drive, rashes and itching, sedation.

Methadone Contraindications

Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride.

Methadone is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory

depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute bronchial asthma or hypercarbia.

Methadone is contraindicated in any patient who has or is suspected of having a paralytic ileus,

low amount of magnesium in the blood, alcohol intoxication, low amount of potassium in the blood, alcoholism, drug abuse and decreased function of the adrenal gland. Consult your doctor for more on this.

Methadone Warnings and Precautions

Before taking methadone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Caution should be exercised in patients with hepatic dysfunction or renal dysfunction.

In the case of the elderly or ill patients repeated dose should only be given with extreme caution. As an opioid, Methadone hydrochloride tablets expose users to the risks of addiction, abuse, and misuse.

Methadone crosses the placenta and can cause fetal dependence. Therefore, the administration of methadone during pregnancy should be limited to patients with an established opiate dependence.

Some people should not take methadone. Tell your doctor if you have:

Heart disease

A heart rhythm disorder

An electrolyte imbalance

Breathing problems or lung disease

A history of head injury, brain tumor, or seizures

Liver or kidney disease

Problems urinating

Gallbladder, pancreas, or thyroid problems